The In’Oss Putty is a unique bone regeneration technology.

The In’Oss Putty offers a revolutionary solution in orthopedic and maxillofacial surgery. Fast bone regeneration, easy application, maximum safety, so your patients can heal faster and you can achieve even better outcomes.

• ✅ Ideal for restoring limb, spine, pelvic, and dental bone defects
• ✅ Can be used alone or combined with autografts
• ✅ Fewer compromises, more successful procedures

It uniquely combines an optimal osteogenic scaffold with a special polymer that accelerates bone formation, ensuring the best outcome for you and your patients.

Composed of MBCP granules, which have proven biocompatible, osteoconductive, and resorbable for over 30 years — giving you a reliable, long-term solution.

The putty is ready to use immediately, and its efficiency is not affected by the presence of blood or saliva, making the procedure simpler and safer.

• Ready to use
  No prior mixing or complex preparation required.
• Putty-like, moldable consistency
  Easily positioned, perfectly adapts to the bone defect.
• Shape-stable
  Remains stable in place even in the presence of biological fluids.
• Osteogenic effect – 3D scaffold
  Supports rapid vascularization and bone regeneration.

World Patent

The French National Research Council registered a world patent for the In’Oss Putty, granting Biomatlante exclusive manufacturing and distribution rights.

Preclinical and Clinical Experience

In’Oss has also been tested in animal models. More than 200 human clinical trials are underway.

Unique Know-How

Biomatlante adapted microporous MBCP particles for easy use.
Particles sized 80–200 microns and spherical in shape were specifically developed for minimally invasive surgical procedures.

Instructions for Use

1. Remove the blister from the pouch.

2. In’Oss™ does not require prior mixing before application. It comes pre-mixed and can be placed directly from the syringe into the bone defect. It can be used alone or as a graft extender with autograft or allograft.

3. In’Oss™ is not a hardening bone graft material, so during healing, complete closure with a membrane or proper sutures is recommended.

What is In’Oss putty made of?

In’Oss putty is a fully synthetic, microporous, biphasic calcium phosphate particle-based osteogenic scaffold putty, containing an aqueous carrier.

Can In’Oss putty cause allergic reactions?

Both calcium phosphate particles and the aqueous polymer have been safely used in medical materials and pharmaceuticals for years, showing no allergic reactions.

Is there a risk of infection transmission with In’Oss putty?

In’Oss putty is fully synthetic, so there is no risk of infection transmission.

How and when does the aqueous carrier of In’Oss putty resorb?

In vivo tests have shown that the carrier is resorbed in less than 2 weeks and replaced by extracellular matrix.

What wound healing characteristics does In’Oss putty have?

In’Oss putty has limited hemostatic and clot-stabilizing effects. Its bioactive phase is osteogenic with rapid resorption and bone formation, supporting tissue healing and fast bone regeneration.

Advantages of In’Oss over xenograft bone?

Xenografts are safe but carry infection risk and slow resorption up to 15 years. In contrast, In’Oss resorbs within a few months and is gradually replaced by new bone.

Advantages of In’Oss over allograft bone?

Unlike allografts, which carry infection and immune reaction risks, the MBCP particles in In’Oss show osteoconductive properties widely validated in literature and clinical studies.

Benefits of using In’Oss in surgical procedures?

In’Oss putty is easily moldable, provides excellent adhesion, and fills bone defects perfectly. Its use simplifies and accelerates surgery while supporting faster healing.

Why stronger together?

The EZ Cure™ collagen membrane and In’Oss™ Putty bone graft complement each other to provide optimal regeneration:

• In’Oss™ Putty: stable and moldable bone graft that stimulates new bone formation.
• EZ Cure™ membrane: long-term barrier (3–6 months) preventing soft tissue invasion.
• Together: guided bone regeneration, faster healing, and predictable results.